Nonimmediate allergic reactions induced by Mesna
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چکیده
منابع مشابه
Nonimmediate allergic reactions induced by Mesna
Mesna (2-mercaptoethane sulfonate Na), a drug that alleviates cyclophosphamide (CYC)-induced hemorrhagic cystitis, is frequently used to treat cancer and collagen diseases. A 33-year-old woman presented with high fever during CYC-based induction therapy for systemic lupus erythematosus. Her final diagnosis was mesna-induced drug hypersensitivity. Although mesna is widely used, allergic reaction...
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Nonimmediate allergic reactions (NIRs) to drugs, which are the most common reactions induced by specific immunologic mechanisms, can be induced by all commercially available drugs. NIRs can appear hours, days, or even weeks after drug intake. They elicit a spectrum of manifestations, mostly affecting the skin, ranging from maculopapular exanthema and urticaria to other less common but more seve...
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PURPOSE OF REVIEW This review presents the current knowledge of the role of T cells in drug allergy manifesting as exanthematous, pustular and bullous skin diseases, collectively referred to as nonimmediate allergic drug reactions. RECENT FINDINGS Both CD4+ and CD8+ T cells producing type 1 and type 2 cytokines and endowed with cytotoxic properties are involved in nonimmediate allergic drug r...
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Nonimmediate drug hypersensitivity reactions (DHRs) are diffi cult to manage in daily clinical practice, mainly owing to their heterogeneous clinical manifestations and the lack of selective biological markers. In vitro methods are necessary to establish a diagnosis, especially given the low sensitivity of skin tests and the inherent risks of drug provocation testing. In vitro evaluation of non...
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ژورنال
عنوان ژورنال: Journal of General and Family Medicine
سال: 2017
ISSN: 2189-7948
DOI: 10.1002/jgf2.79